Table 2.

The classification of SNP effects that can influence the accelerated-aging phenotype in OXYS rats.

Nucleotide Substitution Effect	Impact	Number of SNPs
frameshift_variant	High	4
stop_gained	High	4
stop_lost	High	1
synonymous_variant	Low	338
splice_region_variant, synonymous_variant	Low	5
synonymous_variant, NMD_transcript_variant	Low	1
splice_region_variant, 3_prime_UTR_variant, NMD_transcript_variant	Low	1
missense_variant	Moderate	159
missense_variant, NMD_transcript_variant	Moderate	4
missense_variant, splice_region_variant	Moderate	4
intergenic_variant	Modifier	243
3_prime_UTR_variant	Modifier	533
intron_variant	Modifier	751
downstream_gene_variant	Modifier	1262
upstream_gene_variant	Modifier	414
5_prime_UTR_variant	Modifier	75
non_coding_transcript_exon_variant	Modifier	49
intron_variant, non_coding_transcript_variant	Modifier	38
intron_variant, NMD_transcript_variant	Modifier	12
3_prime_UTR_variant, NMD_transcript_variant	Modifier	5

NMD: nonsense-mediated messenger RNA (mRNA) decay, UTR: untranslated region.