Hyperglycemia in streptozotocin (STZ)-induced diabetic C57BL/6 and Retinoic acid-related orphan receptor gammaT (RORγt) transgenic mice. (A) Assessment of 6-h fasted Blood Glucose in diabetic C57BL/6 (white), RORγt−/− (grey), and RORγt-GFP (black) mice (n = 20/group), 17 days after STZ injections (Day 22). Glycated Hemoglobin A (A1c) in non-diabetic (white) and STZ-induced diabetic (black) mice at 6 weeks (A) and at 29 weeks (C) after diabetic conditions were confirmed in C57BL/6, RORγt−/−, RORγt-GFP, and SR1001 treated mice. Error bars represent the standard error of the mean (SEM), and * p < 0.01. Data are representative of three separate experiments.