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. 2020 May 17;21(10):3547. doi: 10.3390/ijms21103547

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inflammation in diabetic mice injected with RORγt inhibitor—SR1001 (A) Dose-dependent analysis of the efficacy of SR1001 to inhibit IL-17A production in sera 2 months after diabetic conditions were confirmed (n = 3), wherein IL-17A in the sera of non-diabetic (white), diabetic (black), or diabetic C57BL/6 mice treated with 1, 2, or 5 μM of RORγt inhibitor-SR1001 (grey) was quantified by ELISA. ELISA quantifications of IL-17A (B), TNF-α (C), and VEGF (D) in retinas (n = 3) of non-diabetic (white), diabetic (black), or diabetic treated with 5μM of SR1001 (grey) C57BL/6 mice. Error bars represent the SEM, and * p < 0.001, wherein p-value was first equated by two-way ANOVA analysis and then an unpaired t-test with Tukey’s post-hoc analysis. Data are representative of 2 separate experiments with similar results.