Table 2.
A tabulated summary of GI50 values following treatment of TK10 renal carcinoma cells with naked- and AFt-encapsulated antitumor benzothiazoles. MTT assays were conducted following 72 h exposure of cells to test agent. n = 3 per trial; ≥3 independent trials. The mean number of benzothiazole molecules encapsulated per AFt cage is also depicted.
| Benzothiazole | GI50 Value (µM) ± SD | No. Molecules: AFt Cage ± SD | |
|---|---|---|---|
| Naked Agent | AFt-Encapsulated | ||
| 5F 203 | 0.11 ± 0.09 | 0.028 ± 0.004 | 71 |
| Phortress | 6.3 ± 2.9 | 0.098 ± 0.008 | 130 |
| GW 610 | 0.57 ± 0.16 | 0.14 ± 0.09 | 191 |
| GW 608-Lys | 34.1 ± 14 | 0.6 ± 0.35 | 386 |