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. 2020 May 22;21(10):3655. doi: 10.3390/ijms21103655

Figure 5.

Figure 5

In vitro functional analysis of sushi repeat containing X-linked 2 (SRPX2) on endothelial cells and chemosensitivity. (A) The expression and secretion change of SRPX2 by SRPX2-knockdown treatment in HSC3 cells supernatant. (B) The regulation of migration of human umbilical vain endothelial cells (HUVECs) and human dermal lymphatic microvascular endothelial cells (HDLMVECs) by SRPX2. (C) The modulation of adhesion between endothelial cells and HSC3 cells by SRPX2. (D) The conditioned medium (CM) of SRPX2-producing HSC3 cells promotes the proliferation of endothelial cells, whereas their effects are offset by uPAR and HGF antibodies. (E) The influence of SRPX2 on the resistance of HSC3 cells to platinum agents.