Figure 2.

Apolipoprotein-based nanostructures targeting LDLr family of proteins. Nanoparticles bearing ligands, such as apoB-100 or apoE3 or their derivatives, target the LDLr family of proteins. (A) ApoB-100-based peptides with a hydrophobic tail to promote lipid binding. (B) Plasma-derived LDL bearing apoB-100 on the surface and a core of neutral lipids such as CE or triglycerides with hydrophobic molecules incorporated into the core. (C) The core of the LDL particle has been substituted with hydrophobic agents of interest with a surrounding monolayer of amphipathic lipids and apoB-100. (D) ApoB-100 on LDL modified with dextran or dendrimers. (E) ApoE crosslinked to human serum albumin (HSA) nanoparticles. Particle sizes are not to scale.