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. 2020 May 12;21(10):3407. doi: 10.3390/ijms21103407
ALDO Aldosterone
ENaC Epithelial Na+ channel
ISC Short-circuit current
Po Open probability
PI3K Phosphatidylinositide 3’-kinase
PI(4)P5K Phosphatidylinositol-4-phosphate 5-kinase
SGK1 Serum- and glucocorticoid-induced kinase 1
kI The insertion rate of ENaC into the apical membrane for the intracellular store site
kE The endocytotic rate of ENaC from the apical membrane to the intracellular recycling site
kR The recycling rate of ENaC from the recycling state to the insertion state
kD The degradation rate of ENaC from the recycling state to the degradation state
NR Relocation number of ENaC to the apical membrane state
RR The recycling rate of ENaC from the recycling state to the insertion state
ITotal The cumulative Na+ absorption (ISC)
TENaC The total amount of ENaC
TAM The residency time of ENaC in the apical membrane how long an individual ENaC stays in the apical membrane each time after the insertion of ENaC into the apical membrane
TCTAM The cumulative time how long an individual ENaC stays in the apical membrane during its whole life-time period before degradation
TWLT The whole life-time after the first insertion to the apical membrane
Insert Insert state
Apical Apical state
Recycl Recycle state
Degrad Degradation state
Insert (t) The amount of ENaC in the insertion state at time = t after insulin application
Apical (t) The amount of ENaC in the apical membrane state at time = t after insulin application
Recycl (t) The amount of ENaC in the recycling state at time = t after insulin application
Degrad (t) The amount of ENaC in the degradation state at time = t after insulin application
Insert0 Insert(0)
Apical0 Apical(0)
Recycl0 Recycl(0)
Dergad0 Degrad(0)