ALDO |
Aldosterone |
ENaC |
Epithelial Na+ channel |
ISC
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Short-circuit current |
Po |
Open probability |
PI3K |
Phosphatidylinositide 3’-kinase |
PI(4)P5K |
Phosphatidylinositol-4-phosphate 5-kinase |
SGK1 |
Serum- and glucocorticoid-induced kinase 1 |
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The insertion rate of ENaC into the apical membrane for the intracellular store site |
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The endocytotic rate of ENaC from the apical membrane to the intracellular recycling site |
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The recycling rate of ENaC from the recycling state to the insertion state |
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The degradation rate of ENaC from the recycling state to the degradation state |
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Relocation number of ENaC to the apical membrane state |
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The recycling rate of ENaC from the recycling state to the insertion state |
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The cumulative Na+ absorption (ISC) |
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The total amount of ENaC |
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The residency time of ENaC in the apical membrane how long an individual ENaC stays in the apical membrane each time after the insertion of ENaC into the apical membrane |
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The cumulative time how long an individual ENaC stays in the apical membrane during its whole life-time period before degradation |
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The whole life-time after the first insertion to the apical membrane |
Insert |
Insert state |
Apical |
Apical state |
Recycl |
Recycle state |
Degrad |
Degradation state |
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The amount of ENaC in the insertion state at time = after insulin application |
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The amount of ENaC in the apical membrane state at time = after insulin application |
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The amount of ENaC in the recycling state at time = after insulin application |
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The amount of ENaC in the degradation state at time = after insulin application |
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