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Secreted PCSK9 binds to LDLR on the liver surface and mediates the lysosomal degradation of the complex formed by PCK9-LDLR, leading to decreased density of LDLR on the hepatocyte surface and further to increased LDL level in serum. Abbreviations: LDL—low-density lipoprotein; PCSK9—proprotein convertase subtilisin/kexin type 9; LDLR—low-density lipoprotein receptor.
