Table 6.
Group 2. Average annual mean change in score for pre-antidopaminergic and post-antidopaminergic takers and matched controls (SD in brackets)
| Control group (time 1) (n=103) |
Control group (time 2) (n=103) |
P value | Cohen’s d | Pre-antidopaminergic medication (time 1) (n=90) |
Post-antidopaminergic Medication (time 2) (n=90) |
P value | Cohen’s d | |
| UHDRS total motor score | 2.4 (7.9) |
2.7 (7.6) |
0.819 | 0.04 | 5.7 (11.2) |
2.9 (9.2) |
0.079 | 0.27 |
| UHDRS total chorea score | 0.4 (4.5) |
1 (4.2) |
0.344 | 0.14 | 1.1 (4.7) |
−0.5* (5.5) |
0.036 | 0.31 |
| UHDRS saccade initiation | 0.4 (1.4) |
0.1 (1.4) |
0.100 | 0.21 | 0.6 (1.5) |
0.03* (1.7) |
0.020 | 0.35 |
| Irritability (PBA) |
0.4 (4) |
0.6 (3.4) |
0.745 | 0.05 | 0.1 (6.2) |
−1.8 (6.2) |
0.065 | 0.31 |
| Depression (PBA) |
−0.1 (4.1) |
−0.1 (4.5) |
0.962 | 0 | 0.8 (6.2) |
−0.2 (6.7) |
0.508 | 0.2 |
| Apathy (PBA) |
0.02 (2.9) |
0.3 (3.3) |
0.474 | 0.09 | 0.3 (4) |
0.9 (4.9) |
0.396 | 0.13 |
| Total composite cognitive z-score | 0.4 (3.9) |
−0.3 (4) |
0.199 | 0.18 | 0.8 (3.4) |
−0.7*** (3.4) |
0.001 | 0.44 |
| TFC score | −0.6 (1.3) |
−0.4 (1.6) |
0.483 | 0.13 | −0.9 (1.8) |
−1 (1.6) |
0.664 | 0.05 |
| UHDRS independence scale | −3.1 (7.6) |
−1.8 (9.5) |
0.3 | 0.15 | −5.2 (9.5) |
−3.6 (7.3) |
0.183 | 0.18 |
P values are from paired t-tests.
*Indicates a significant difference (p<0.005) when compared with the control non-antidopaminergic medication group.
†Indicates a significant difference (p<0.001) when compared with the control non-antidopaminergic medication group.
PBA, problems behavioural assessment; TFC, total functional capacity; UHDRS, Unified Huntington Disease Rating Scale.