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. 2020 Apr 9;91(6):612–621. doi: 10.1136/jnnp-2019-322493

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the license is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Relationship between NPTX2 and (A) frontal lobe volume (n=126), (B) insular volume (n=126), (C) Mini Mental State Examination (MMSE) (n=145) and (D) Clinical Dementia Rating scale (CDR) plus FTD modules (n=120) among mutation carriers. b and p were obtained through multiple linear regression with square-root transformed NPTX2 as the dependent variable, adjusting for age, gender and study site; for MMSE, we also included years of education as a covariate. CSF, cerebrospinal fluid; FTD, frontotemporal dementia; NPTX, neuronal pentraxin; TIV, total intracranial volume.