Table 2.

Relationship between NPTX2 and grey matter volume. Results were obtained through multiple linear regression with square-root transformed NPTX2 as dependent variable, adjusting for age, gender and study site. All grey matter volumes were corrected for total intracranial volume

	All mutation carriers (n=126)	Symptomatic mutation carriers (n=35)	Presymptomatic mutation carriers (n=91)
Whole brain volume
b (SE)	1.07 (0.25)	1.21 (0.42)	0.58 (0.39)
β	0.533	0.585	0.215
p	<0.001*	0.007*	0.145
Frontal lobe
b (SE)	3.86 (0.83)	4.40 (1.33)	3.48 (1.44)
β	0.516	0.623	0.331
p	<0.001*	0.003*	0.018
Temporal lobe
b (SE)	4.01 (1.32)	5.00 (2.27)	0.67 (2.11)
β	0.338	0.448	0.039
p	0.003*	0.037	0.752
Parietal lobe
b (SE)	4.89 (1.77)	5.51 (4.25)	2.70 (2.18)
β	0.323	0.319	0.169
p	0.007*	0.208	0.218
Occipital lobe
b (SE)	1. 45 (1.77)	-6.65 (4.03)	3.10 (1.97)
β	0.086	-0.341	0.185
p	0.412	0.112	0.119
Cingulate gyrus
b (SE)	10.49 (5.27)	14.72 (11.32)	0.46 (7.27)
β	0.205	0.285	0.008
p	0.049	0.206	0.95
Insula
b (SE)	37.22 (8.69)	69.21 (13.09)	12.61 (13.16)
β	0.482	0.786	0.119
p	<0.001*	<0.001*	0.341

P values marked with an asterisk remained significant after Bonferroni correction. b indicates unstandardised regression coefficient. β indicates standardised regression coefficient.

NTPX, neuronal pentraxin.