Table 3.

Relationship between NPTX2 and disease severity scores, obtained through multiple linear regression with square-root transformed NPTX2 as dependent variable, adjusting for age, gender, study site and, in analyses of MMSE, TMT-B and letter fluency, years of education

	All mutation carriers	Symptomatic mutation carriers	Presymptomatic mutation carriers
MMSE
n	145	50	95
b (SE)	1.21 (0.26)	0.98 (0.29)	1.58 (0.79)
β	0.442	0.467	0.23
p	<0.001*	0.002*	0.051
TMT-B
n	125	34	91
b (SE)	−0.04 (0.01)	−0.02 (0.02)	−0.09 (0.04)
β	−0.353	−0.234	−0.259
p	<0.001*	<0.001*	0.03
Phonemic verbal fluency
n	132	39	93
b (SE)	0.14 (0.05)	0.15 (0.10)	0.05 (0.08)
β	0.255	0.25	0.076
p	0.009*	0.151	0.536
CDR plus FTD modules
n	120	33	87
b (SE)	−0.85 (0.19)	−0.72 (0.24)	−1.19 (1.67)
β	−0.435	−0.479	−0.078
p	<0.001*	0.007*	0.478
CBI-R
n	119	40	79
b (SE)	−0.13 (0.03)	−0.10 (0.04)	−0.02 (0.14)
β	−0.489	−0.394	−0.014
p	<0.001*	0.017*	0.906

P values are before multiple testing correction; p values marked with an asterisk remained significant after Bonferroni correction. b indicates unstandardised regression coefficient; β indicates standardised regression coefficient.

CBI-R, Revised Cambridge Behavioural Inventory; CDR, Clinical Dementia Rating scale; MMSE, Mini Mental State Examination; TMT-B, Trail Making Test part B.