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. 2020 May 22;21(10):3659. doi: 10.3390/ijms21103659

Figure 3.

Figure 3

Effect of SIRTi in T. cruzi sirtuin deacetylation activity. Inhibitory effect of SIRTi in the deacetylation activity of TcSir2rp1 (A) and TcSir2rp3 (B). Compounds with inhibitory effect higher than 30% are highlighted in orange. Binding pose of 15 and 17 into TcSir2rp1 modeled structures (C); poses of 8, 12, 13, 30, and 32 docked into TcSir2rp3 (D). In gold and gray are also reported the protein alpha carbon atom traces. In blue the area normally occupied by NAD+ or ADP-ribose structures. In green is depicted the area where were found the experimental bound inhibitors/activators used in the docking assessments.