Table 1.

IC₅₀ values of SIRTi with best deacetylation inhibitory activity against T. cruzi sirtuins.

Compounds	TcSir2rp1	TcSir2rp3
	IC50 ± SD (µM) a	IC50 ± SD (µM) a
8	ND	18.8 ± 5.34
12	ND	14.3 ± 6.06
13	ND	18.5 ± 1.97
15	32.4 ± 7.88	ND
17	25.5 ± 4.73	ND
31	ND	16.3 ± 9.54
32	ND	16.4 ± 6.70

^a Sirtuin activity was determined 4 h after incubation.