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. 2020 May 21;21(10):3631. doi: 10.3390/ijms21103631

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Noradrenaline uptake and release from cortical synaptosomes of young and old mice: effects of chronic EAm treatment. (a) total [³H]noradrenaline ([³H]NA) content (expressed as nCi) in cortical synaptosomes from EAm-untreated (empty bar) or EAm-treated (gray bar) young and old mice. (b) spontaneous basal release (expressed as percentage of tritium in the first collected superfused fraction, with respect to the total tritium synaptosomal content) in cortical synaptosomes from the four animal groups. (c) 12 mM KCl-evoked [³H]noradrenaline release (expressed as percentage of tritium released over the basal outflow with respect to the total tritium synaptosomal content) in cortical synaptosomes from the four animal groups. Data represent the mean± S.E.M. from nine untreated young mice, eight EAm-treated young mice, nine untreated old mice, nine EAm-treated old mice, from both of the two trials. Statistical analysis was performed by applying ANOVA followed by the Tukey’s Multiple Comparison test. * p < 0.05 vs. EAm-untreated young mice; ## p < 0.01 vs. EAm-untreated old mice.

Noradrenaline uptake and release from cortical synaptosomes of young and old mice: effects of chronic EAm treatment. (a) total [³H]noradrenaline ([³H]NA) content (expressed as nCi) in cortical synaptosomes from EAm-untreated (empty bar) or EAm-treated (gray bar) young and old mice. (b) spontaneous basal release (expressed as percentage of tritium in the first collected superfused fraction, with respect to the total tritium synaptosomal content) in cortical synaptosomes from the four animal groups. (c) 12 mM KCl-evoked [³H]noradrenaline release (expressed as percentage of tritium released over the basal outflow with respect to the total tritium synaptosomal content) in cortical synaptosomes from the four animal groups. Data represent the mean± S.E.M. from nine untreated young mice, eight EAm-treated young mice, nine untreated old mice, nine EAm-treated old mice, from both of the two trials. Statistical analysis was performed by applying ANOVA followed by the Tukey’s Multiple Comparison test. * p < 0.05 vs. EAm-untreated young mice; ## p < 0.01 vs. EAm-untreated old mice.