Table 4.
Evaluation of intertumoral heterogeneity in multiple breast carcinoma.
| No. | No of foci | Size (mm) | Grade of Differentiation | Histotype | Molecular Subtype | Metastases | ||
|---|---|---|---|---|---|---|---|---|
| Grade | Histotype | Molecular Subtype | ||||||
| 1 | 2 | 10/10 | 1/1 | D/D | LuA/LuA | |||
| 2 | 2 | 12/5 | 1/2 | D/D | LuA/LuA | |||
| 3 | 2 | 11/3 | 1/2 | D/D | LuA/LuA | |||
| 4 | 2 | 11/4 | 2/2 | D/D | LuA/LuA | |||
| 5 | 2 | 12/5 | 2/2 | D/D | LuA/LuA | |||
| 6 | 2 | 12/10 | 2/2 | D/D | LuB/LuA | |||
| 7 | 2 | 12/11 | 2/2 | D/D | TN/TN | |||
| 8 | 2 | 15/15 | 2/2 | MX | LuA/LuA | |||
| 9 | 2 | 16/12 | 2/3 | D/L | LuA/LuB | 3 | D | LuA |
| 10 | 2 | 18/18 | 2/3 | D/D | LuA/LuB | 3 | D | |
| 11 | 3 | 20/10/3 | 2/2/2 | D/D/L | LuA/LuA/LuA | 2 | D | LuA |
| 12 | 3 | 20/11/3 | 2/2/2 | D/D/D | LuA/LuB/LuA | |||
| 13 | 3 | 20/11/2 | 2/2/2 | D/D/D | LuB/LuB/LuB | |||
| 14 | 3 | 21/5/5 | 2/2/2 | D/D/D | LuB/LuA/LuA | |||
| 15 | 3 | 26/4/3 | 3/3/3 | D/D/D | LuA/LuA/LuA | 3 | D | LuA |
| 16 | 4 | 17/5/5/3 | 2/2/2/2 | D/D/D… | LuA/LuA/LuA… | |||
| 17 | 4 | 18/6/6/4 | 2/2/2/2 | D/D/D… | TN/TN/TN… | 3 | D | LuB |
| 18 | 4 | 23/11/5/5 | 2/2/2/2 | MX | LuA/LuA/LuA… | 2 | D | LuB |
| 19 | 4 | 26/4/4/2 | 3/3/3/3 | D/D/D… | LuA/LuA/LuA… | 2 | D | LuA |
| 20 | 5 | 36/12/4/4/3 | 3/3/3/3/3 | M/M/M… | TN/TN/TN… | 3 | M | TN |
| 21 | 6 | 22/11/6/6/4/1 | 2/2/2/2/2/2 | L/L/L | LuA/LuA/LuA… | |||
| 22 | 7 | 20/11/7/4/4/2/1 | 2/2/2/2/2/2/2 | D/D/D… | LuA/LuA/LuA… | 2 | D | LuA |
| 23 | 7 | 20/12/7/4/5/2/1 | 2/3/2/2/2/2/1 | D/D/D… | LuA/LuA/LuA… | |||
| 24 | 7 | 21/11/7/4/4/2/1 | 2/3/3/2/2/2/2 | D/D/D… | LuB/LuA/LuA… | |||
| 25 | 7 | 26/18/7/4/4/2/1 | 2/3/3/3/3/2/2 | D/L/L | LuA/LuA/LuA… | 3 | L | LuA |
| 26 | 8 | 18/10/3/2/2/1/1/1 | 2/2/2/2/2/2/2/2 | L/L/L | HER/HER/HER… | 2 | L | HER |
| 27 | 8 | 23/11/5/4/2/1/1/1 | 2/2/2/3/2/1/1/1 | D/D/D… | LuA/LuA/LuA… | |||
| 28 | 8 | 28/12/4/3/3/1/1/1 | 2/2/2/2/1/1/1/1 | D/D/D… | LuA/LuA/LuA… | 2 | D | LuB |
| 29 | 8 | 30/10/3/2/2/1/1/1 | 3/3/3/3/3/3/3/3 | D/D/D… | TN/TN/TN… | 3 | D | TN |
| 30 | 9 | 25/14/3/2/1/1/1/1… | 2/2/2/2/1/1/1/1/1 | D/D/D… | LuB/LuB/LuB… | |||
| 31 | 9 | 38/10/6/2/2/1/1/1… | 3/3/3/3/3/3/3/3/3 | L/L/L… | LuA/LuA/LuA… | 3 | L | LuA |
| 32 | 10 | 26/15/4/4/2/2/1/1… | 2/2/2/1/1/1/1/1/1/1 | D/D/D… | LuA/LuB/LuA… | 2 | D | LuB |
| 33 | 10 | 27/10/5/5/2/1/1/1… | 2/2/2/2/2/2/2/2/2/2 | D/D/D… | LuA/LuB/LuA… | 3 | D | TN |
| 34 | 11 | 10/10/5/2/2/1/1/1… | 3/2/2/2/2/2/2/2/2/2/2 | D/D/D… | TN/TN/TN… | 3 | D | TN |
| 35 | 11 | 18/12/3/3/2/1/1/1… | 2/2/2/2/2/2/2/2/2/2/2 | D/D/D… | LuB/LuB/LuB… | |||
| 36 | 11 | 32/18/4/4/2/1/1/1… | 2/2/2/2/2/2/2/2/2/2/2 | L/L/L… | LuA/LuA/LuA… | 2 | L | LuA |
| 37 | 11 | 35/10/3/2/2/1/1/1… | 3/3/3/3/3/3/3/3/3/3/3 | L/L/L… | LuA/LuA/LuA… | 3 | L | LuA |
D = Ductal Carcinoma (NST); L = Invasive Lobular Carcinoma; MX = Mixt Carcinoma; M = Carcinoma with Medullary Characteristics; LuA = Luminal A; LuB = Luminal B; TN = Triple Negative; HER = HER2-enriched. Highlighted rows—multicentric carcinoma; non-highlighted rows—multifocal carcinoma; Numbers in bold—the dominant tumor.