Table 1.

Role of integrins on FAK family signaling in vascular cell types.

Cell Type	Integrin	Function	Reference
Vascular smooth muscle cells	α5β1	Binds fibronectin and promotes FAK activation	[34]
	αvβ3	Binds fibronectin and promotes FAK activation	[34]
		Promotes FAK activation upon binding to osteoprotegerin under hypoxic conditions	[35]
	α5	Dual knockout using SM22α-Cre reduced FAK activity and tyrosine phosphorylation of downstream target proteins	[36]
	αv
Endothelial cells	α5β1	Promotes flow-induced FAK-mediated NF-κB transcriptional activation	[37]
		Promotes disturbed flow activation of FAK	[38]
		Mediates oxidized LDL activation of FAK	[39]
	α1β1	Increases FAK activation upon binding to semaphorin 7A	[40]
	αvβ3	Promotes flow-induced FAK-mediated NF-κB transcriptional activation	[37]
		Promotes high shear flow-induced FAK expression and inflammatory gene expression	[41]
Cardiomyocytes	β3	Increased association with FAK in pressure-overloaded hypertrophic hearts	[42]
Platelets	αIIbβ3	Activates FAK upon binding fibrinogen in conjunction with costimulatory molecules like ADP, epinephrine, and thrombin	[43]
		Activates Pyk2 upon binding fibrinogen to promote phosphorylation of c-Cbl	[44]
	α2β1	Activates Pyk2 to promote aIIbb3 inside-out signaling	[45]