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. 2020 May 24;21(10):3693. doi: 10.3390/ijms21103693

Table 1.

miRNA deregulation in head and neck cancer and validated targets.

Cancer Type miRNA Regulation Role Target Gene Ref.
Laryngeal cancer
(LCa)		 Let-7a Down Tumor-suppressive HMGA2 [43]
miR-1 Down Tumor-suppressive FN1 [25,35]
miR-9 Up Oncogenic PTEN [23]
miR-9 Up Oncogenic - [109]
miR-10b Up Oncogenic CDH1 [24]
miR-21 Up Oncogenic BTG2, PTEN, TPM1, PDCD4, CDK2AP1 [25]
miR-23a Up Oncogenic - [107]
miR-24 Down Tumor-suppressive XIAP [36]
miR-34a Down Tumor-suppressive CCND1, GALNT7 [38,40]
miR-34c Down Tumor-suppressive c-Met, GALNT7 [39,40]
miR-93 Up Oncogenic CCNG2 [28,29]
miR-101 Down Tumor-suppressive CDK8 [108]
miR-126 - Tumor-suppressive Camsap1 [30]
miR-132 Up Oncogenic FOXO1 [31]
miR-138-2-3p Up Oncogenic - [122]
miR-144 Down Tumor-suppressive IRS1 [41]
miR-203 Down Tumor-suppressive - [121]
miR-205 Up Oncogenic CDK2AP1 [27]
miR-221 - Oncogenic ER-α, p27, p57, c-kit, Apaf-1 [32]
miR-296-5p Up Oncogenic - [110]
miR-302-3p Up Oncogenic Smad4 [33]
miR-340 Down Tumor-suppressive p27, EZH2 [42]
miR-423-3p Up Oncogenic AdipoR2 [34]
Head and neck squamous cell carcinoma
(HNSCC)		 miR-1 Down Tumor-suppressive TAGLN2 [65]
miR-1 Down Tumor-suppressive EGFR, c-Met [70]
miR-10b Down Tumor-suppressive - [45]
miR-99 Down Tumor-suppressive IGF1R, mTOR, Akt1 [76,77]
miR-100 Down Tumor-suppressive IGF1R, mTOR, Akt1 [76,77]
miR-101 Down Tumor-suppressive EZH2, rap1GAP [81,82]
miR-146a Down Tumor-suppressive - [50]
miR-155 Down Tumor-suppressive - [50]
miR-196a Up Oncogenic - [45]
miR-203 Up Oncogenic - [54]
miR-203 Down Tumor-suppressive - [56]
miR-204 Down Tumor-suppressive Brd4 [91]
miR-205 Up Oncogenic - [54]
miR-206 Down Tumor-suppressive EGFR, c-Met [70]
Oral squamous cell cancer
(OSCC)		 miR-1 Down Tumor-suppressive Slug [68]
miR-1-3p Down Tumor-suppressive DKK1 [69]
miR-26a/b Down Tumor-suppressive TMEM184B [71]
miR-34a Down Tumor-suppressive - [74]
miR-99-3b Down Tumor-suppressive glycogen synthase kinase-3β [80]
miR-99a Down Tumor-suppressive Myotubularin-related protein 3 [78,79]
miR-104-5p Down Tumor-suppressive PAK4 [86]
miR-155 Up Oncogenic - [141]
miR-155 Up Oncogenic CDC73 [47,48,49]
miR-181a Down Tumor-suppressive K-ras [52]
miR-181a/b Up Oncogenic - [51]
miR-204 Down Tumor-suppressive Sox4, Slug [88]
miR-204-5p Down Tumor-suppressive CXCR4 [89]
miR-222 Up Oncogenic PUMA [60]
miR-222 Down Tumor-suppressive PUMA [127]
miR-223 Up Oncogenic - [62]
miR-223 Up Oncogenic FBXW7 [63]
miR-494 Down Tumor-suppressive HOXA10 [90]
Oral miR-10b Up Oncogenic - [44]
Oral tongue squamous cell carcinoma
(OTSCC)		 miR-222 Down Tumor-suppressive MMP1, SOD2 [61]
Hypopharyngeal squamous cell carcinoma
(HSCC)		 miR-140-5p Down Tumor-suppressive ADAM10 [85]
Maxillary sinus miR-1 Down Tumor-suppressive TAGLN2, PNP [66]
Nasopharyngeal carcinoma
(NPC)		 miR-1 Down Tumor-suppressive ET-1 [67]
miR-10b Down Tumor-suppressive - [46]
miR-101 Down Tumor-suppressive ITGA3 [83]
miR-204 Down Tumor-suppressive Cdc42 [90]
miR-494-3p Up Oncogenic Sox7 [93]
Salivary adenoid cystic carcinoma
(SACC)		 miR-104-5p Down Tumor-suppressive Survivin [87]
miR-181a Down Tumor-suppressive MAP2K1, MAPK1, Snai2 [53]
Salivary gland adenoid cystic carcinoma
(SGACC)		 miR-101-3p Down Tumor-suppressive Pim-1 [128]
Sinonasal squamous cell carcinomas
(SN-SCC)		 miR-34a Down Tumor-suppressive BCL-2 [75]
Tongue miR-21 Up Oncogenic - [148]
miR-183 Up Oncogenic - [148]
Tongue squamous cell carcinoma
(TSCC)		 miR-26a Down Tumor-suppressive DNMT3B [72]
miR-26a Down Tumor-suppressive PAK1 [73]
miR-26b Down Tumor-suppressive PAK1 [73]
miR-140-5p - Tumor-suppressive LAMC1, HDAC7, PAX6 [84]
miR-181a Down Tumor-suppressive Twist1 [126]