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During stress situations, like drug addiction, HSP-27 functions as an excellent cardioprotective protein due to its properties as a chaperone and also in the stabilization of actin filaments. In these situations, HSP-27 is translocated to the Z bands in order to stabilize the actin myofilaments, protecting its degradation. During morphine withdrawal, HSP-27 could protect cardiac troponin T (cTnT) from µ-calpain degradation, whose expression is increased during withdrawal symptoms.
