Table 1.

Gene regulation by miRNAs in trophoblast cells.

miRNA	Target Genes	Reference	Effect of Higher miRNA Expression
let-7	ARID3A, ARID3B, HMGA1, cMYC	[11]	Reduces proliferation and invasiveness of trophoblast cells
miR-384	STAT3	[38]
miR-106b	MMP-2	[39]
miR-203	VEGFA	[40]
miR-520g	MMP-2	[41]
miR-210	Notch1	[42]
miR-16	Notch2	[43]
miR-320a	IL-4	[44]
miR-320a	ERRγ	[45]
miR-210-3p	FGF1	[46]
miR-7	EMT-related TFs	[47]	Reduces migration and invasion of trophoblast cells
miR-218	SOX4	[48]
miR-34a-5p	Smad4	[49]
miR-193b-3p	TGF-β2	[50]
miR-34a	MYC	[51]
miR-519d	MMP-2	[52]
miR-101	CXCL6	[53]
miR-34a	Notch	[54]
miR-431	ZEB1	[55]
miR-145-5p	Cyr61	[56]
miR-134	ITGB1	[57]
miR-27a-3p	USP25	[58]
miR-362-3p	Pax3	[59]
miR-181a-5p	IGF2BP2	[60]
miR-137	FNDC5	[61]
miR-30b	MXRA5	[62]
miR-30a-3p	IGF1	[63]
miR-18b	HIF-1α	[64]
miR-299	HDAc2	[65]
miR-454	ALK7	[66]	Increases proliferation of trophoblast cells
miR-145	MUC1	([67]
miR-221-3p	THBS2	[68]
miR-126a-3p	ADAM9	[69]
miR-483-3p	RB1CC1	[70]
miR-144	PTEN	[71]
miR-518b	Rap1b	[72]
miR-218-5p	TGFB2	[73]	Promotes endovascular extravillous trophoblast cells (enEVTs) and spiral artery remodeling
miR-210	CPEB2	[74]	Inhibits trophoblast syncytialization
miR-106a	hCYP19A1, hGCM1	[75]
miR-558	TIMP4	[76]	Enhances invasion of trophoblast cells
miR-576-5p	TFAP2A	[77]
miR-184	WIG1	[78]	Promotes apoptosis of trophoblast cells
miR-133	Rho/ROCK	[79]
miR-152	Bax, Bcl-2	[80]
miR-155	HIF-1α	[81]
miR-371a-5p	XIAP	[82]
miR-520	PARP1	[83]
miR-34a	BCL-2	[84]
miR-18a	ER1	[85]
miR-182	BRCA1	[86]
miR-23a	XIAP	[87]
miR-101-3p	mTOR	[88]
miR-96-5p	mTOR, Bcl-2	[88]
miR-200c	Wnt/β-catenin	[89]
miR-125a	MCL1	[90]