Table 2.
Over-expressed (p < 0.05) biological pathways examined with KEGG database in blastocysts collected six days after seminal plasma infusions prior to insemination relative to control blastocysts.
| Pathway ID | Pathway Name | Enrichment Score | Genes Altered (%) |
Gene List |
|---|---|---|---|---|
| SSC04520 | Adherents junctions | 5.3 | 6.7 | PTRJ, MAPK1, SMAD2 |
| SSC04218 | Cellular senescence | 4.6 | 3.6 | MAPK1, SMAD2, CDK1 |
| SSC04926 | Relaxin signaling | 3.9 | 6.9 | MAPK1, Smad2, COL4A1 |
| SSC04550 | Signaling pathways regulating pluripotency of stem cell | 3.9 | 3.9 | Smad2, MAPK1, Hesx1 |
| SSC04110 | Cell cycle | 3.5 | 3.4 | Smad2, Stag1, CDK1 |
| SSC04371 | Apelin signaling | 3.5 | 3.4 | PRKAA1, SMAD2, MAPK1 |
| SSC04979 | Cholesterol metabolism | 3.3 | 5.1 | ApoA-I |
| SSC04068 | FoxO signaling | 3.3 | 3.1 | PRKAA1, SMAD2, MAPK1 |
| SSC04140 | Autophagy–animal | 3.3 | 3.1 | PRKAA1, ATG4C, MAPK1 |
| SSC04910 | Insulin signaling | 3.3 | 3.1 | PRKAA1, GYS1, MAPK1 |
| SSC04150 | mTOR signaling | 3.1 | 2.9 | MAPK1, PRKAA1, RICTOR |
| SSC04115 | P53 signaling | 3.1 | 4.5 | CDK1, IGF-BP3 |