Table 1.

microRNAs associated with ECM degradation in DDD and their corresponding targets. MMP: matrix metalloproteinases; IL-6/STAT3: interleukin-6/signal transducer and activator of transcription 3; GDF5: growth differentiation factor 5; SOX9: SRY-box transcription factor 9; PTEN: phosphatase and tensin homolog protein.

microRNA	Target	Reference
miR-93	MMP-3	Jing et al. (2015) [41]
miR-193-3p	MMP-14	Ji et al. (2016) [42]
miR-27b	MMP-13	Li et al. (2016) [43]
miR-133a	MMP-9	Xu et al. (2016) [44]
miR-98	IL-6/STAT3	Ji et al. (2016) [45]
miR-132	GDF5	Liu et al. (2017) [46]
miR-7	GDF5	Liu et al. (2016) [47]
miR-494	SOX9	Kang et al. (2017) [48]
miR-21	PTEN	Liu et al. (2014) [49]