Table 1.

Bone metastases characteristics [15].

Types	Pathophysiology	Primary Cancer Sites
Osteolytic	Destruction of normal bone by ostoclasts	Multiple myeloma, melanoma, non-small cell lung cancer, non-Hodgkin lymphoma, thyroid cancer or Langerhans-cell histiocytosis, breast cancer, renal cell carcinoma
Osteoblastic	Deposition of new bone by osteoblasts	Prostate cancer, small cell lung cancer, Hodgkin lymphoma or medulloblastoma
Mixed	Osteolytic and osteoblastic lesions or both types present in the same lesion	Breast cancer, gastrointestinal (GI) cancer and squamous cancer