Table 5.

Characteristics of the two main classes of antiresorptives [28].

Drug	Advantages	Disadvantages
N-BPs	Bone selectivity, inexpensive, longtime use, apoptosis of osteoclasts inductors (but don’t eliminate them)	Effects on renal functions, atypical femoral fractures (osteonecrosis of the jaw), GI adverse effect, acute phase reactions
Denosumab	No effect on renal function, low frequency of administration, no bone accumulation, reversible effects	No bone selectivity, atypical femoral fractures, increased risk of infections, parenteral administration, reduction in bone formation, rebound bone resorption