Figure 2.

Shown are human RNA binding proteins (RBPs) (together with associated family members) playing a major role in acute leukemias as discussed in this review. Domains are color-coded and derived from their respective entry at UniProt [69], unless stated differently. Proteins are scaled to amino acid (AA) length. Black bars indicate intrinsically disordered regions predicted by IUPred2A [70]. RRM, RNA recognition motif; NLS, nuclear localization signal; KNS, hnRNP K-specific nuclear shuttling signal; KI, K protein interactive domain; KH, hnRNP K homology domain; RBR, RNA binding region; ZF, zinc finger domain. The conjugation with the small ubiquitin-related modifier (SUMO) of hnRNP K is indicated with a blue ball. Phosphorylations of ZFP36L1 discussed in this review are indicated with yellow-core balls.