Table 1.
General overview of leukemia-related RNA binding proteins (RBPs), their localization [44] and disease properties.
| RBP | Affected Leukemia Type | Localization | Proliferation Apoptosis Differentiation | Clinical Prognosis (When Altered) | ||
|---|---|---|---|---|---|---|
| P | A | D | ||||
| IGF2BP | AML/ALL | Nucleus | ↑ | Poor | ||
| MSI2 | AML/ALL | Cytosol | ↑ | ↓ | Poor | |
| RBM15 | - | Nucleoplasm | ↓ | ↑ | n/a- | |
| RBM15-MKL1 | AML/ALL | Nucleus | ↑ | Poor | ||
| hnRNP K | AML | Nucleoplasm/Cytosol | ↓ | ↑ | Unknown | |
| Nucleolin | AML | Nucleoplasm, Nucleoli | ↑ | Poor | ||
| ZFP36L1/2 | AML/ALL | Nucleus, Cytoplasm | ↓ | ↑ | Unknown | |
| WT1 | ALL | Nucleoplasm | ↑ | Poor | ||