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. 2020 May 22;21(10):3667. doi: 10.3390/ijms21103667

Figure 4.

Figure 4

Tubular damage in day 7 unilateral ureteric obstruction (UUO) kidney compared to normal controls for WT (closed circles) and CypA−/− (open circles) mice. (A) RT-PCR analysis of CypA mRNA levels in WT mice. (B) Secretion of CypA in response to stimulation by angiotensin II or TNF in primary cultures of WT tubular epithelial cells. Periodic acid-Schiff stained kidney sections of (C) WT UUO and (D) CypA−/− UUO. Bar = 100 μm. (E) Tubular damage score. RT-PCR for mRNA levels of: (F) KIM1, and (G) Klotho. Data are mean ± SD. *** P < 0.0001 versus WT sham control; NS, not significant.