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. 2020 May 24;21(10):3695. doi: 10.3390/ijms21103695

Figure 1.

Figure 1

The expression of pro-apoptotic members of the Bcl-2 family is upregulated, and miR-23a-3p is downregulated in the cortex and hippocampus of irradiated mice. Tissues and neurons were collected at 30 min, 6 h, 24 h, and 7 days after 10 Gy whole-brain irradiation. Total RNA was used for qPCR analysis. qPCR quantification of Puma, Noxa, Bax mRNA levels (A); and miR-23a-3p (B) in cortex, hippocampus, and ex vivo neurons, n = 6/group for brain tissues, n = 5/group for ex vivo neurons, with two technical replicates. Data represent the mean ± SD of one-way ANOVA and Tukey post-hoc analysis, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control animals.