Table 3.

Multivariable adjusted adverse outcomes using platelet nadir, absolute change in platelets, and percent change in platelets as continuous variables.

	Platelet Nadir		% Change in Platelets		Absolute Change in Platelets
Adverse outcome	Odds Ratio (95% CI)	P value	Odds Ratio (95% CI)	P value	Odds Ratio (95% CI)	P value
In-Hospital death
Unadjusted	0.954 (0.940-0.968)	<.0001	0.922 (0.896-0.950)	<.0001	0.994 (0.989-1.000)	.06
Multivariable adjusted	0.955 (0.934-0.975)	<.0001	0.935 (0.899-0.972)	<.001	0.995 (0.987-1.002)	.17
Infection
Unadjusted	0.992 (0.987-0.997)	.002	0.978 (0.966-0.991)	<.001	0.997 (0.994-1.000)	.06
Multivariable adjusted	0.992 (0.986-0.999)	.03	0.984 (0.970-0.999)	.03	0.998 (0.994-1.001	.19
Stroke
Unadjusted	0.975 (0.963-0.988)	<.001	0.946 (0.919-0.973)	<.001	0.996 (0.989-1.002)	.16
Multivariable adjusted	0.974 (0.956-0.992)	.006	0.953 (0.918-0.987)	.01	0.996 (0.988-1.005)	.39
Acute kidney injury
Unadjusted	0.993 (0.990-0.997)	<.001	0.993 (0.984-1.002)	.12	1.000 (0.998-1.002)	.97
Multivariable adjusted	0.993 (0.988-0.998)	.01	0.991 (0.980-1.002)	.10	1.000 (0.997-1.002)	.72
Stage 3 acute kidney injury
Unadjusted	0.969 (0.959-0.980)	<.0001	0.955 (0.935-0.976)	<.0001	0.999 (0.994-1.005)	.83
Multivariable adjusted	0.966 (0.951-0.982)	<.0001	0.967 90.941-0.995)	.02	0.966 (0.951-0.982)	<.0001
Intensive care unit stay > 72 hours
Unadjusted	0.991 (0.988-0.994)	<.0001	0.971 (0.963-0.979)	<.0001	0.991 (0.988-0.994)	<.0001
Multivariable adjusted	0.986 (0.981-0.991)	<.0001	0.972 (0.962-0.982)	<.0001	0.986 (0.981-0.991)	<.0001
Length of stay*
Unadjusted	0.998 (0.997-0.998)	<.0001	0.995 (0.993-0.998)	<.0001	0.998 (0.997-0.998)	<.0001
Multivariable adjusted	0.998 (0.997-0.999)	.001	0.997 (0.995-0.999)	.01	0.998 (0.997-0.999)	.001

Abbreviation: CI, confidence interval.

^*Length of stay was fitted to a negative binomial model.