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. 2020 Jun 4;8(1):e000253. doi: 10.1136/jitc-2019-000253

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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miR-340 is negatively correlated with the expression of CD47 and overall survival in PDAC. (A) Analyses of CD47 expression in normal pancreas (n=16) and pancreatic carcinoma tissues (n=36) by the Oncomine database (p<0.001). (B) The Cox regression analysis revealed a correlation between higher CD47 expression and a poorer prognosis in 172 patients with PDAC analyzed using the LinkedOmics database (p=0.011). (C) Bioinformatics predictions of miRNAs targeting CD47 by miRanda, DIANA-microT and TargetScan. (D) LinkedOmics-identified miRNAs that were significantly negatively correlated with CD47 in PDAC, LUAD and SKCM. (E) The correlative analysis of miR-340 and CD47 in human LUAD (n=32), (F) SKCM (n=97) and (G) PDAC (n=178). (H) Heat map of miRNAs that were negatively correlated with CD47 in PDAC. (I) Analyses of miR-340 expression in normal pancreas (n=4) and pancreatic carcinoma tissues (n=178) by starBase (p=0.043). (J) Cox regression analysis performed using the LinkedOmics database revealed a correlation between miR-340 and survival probability in 172 patients suffering from PDAC (p<0.001). (K) Graphs show the impact of radiation therapy on the expression of miR-340 in PDAC (p=0.039). The data in A and I were analyzed by two-tailed, unpaired t-test. The data in B and J were analyzed by the log-rank Mantel–Cox test. Spearman correlation analysis was used in E–G. The data in K were analyzed using a two-sided Wilcox test. LUAD, lung adenocarcinoma; PDAC, pancreatic ductal adenocarcinoma; SKCM, skin cutaneous melanoma.