Figure 4. Sutent monotherapy improved maturation of vasculature and expression of adhesion molecules associated with leukocyte transmigration. The representative images of VE7D and SU9D tumors stained with CD31 (red) and (A) α-sma+, (C) ICAM-1, (E) VCAM-1 (green) (bar: 100 μm). Quantitation of the data from fluorescent images showed increased expression of (B) α-sma+ (D) ICAM-1 (F) VCAM-1 on CD31+ endothelial cells within Sutent-treated tumors.