Extended Data Figure 7. RIPK1 deficiency in keratinocytes causes extensive transcriptional changes in the skin.

a, Differential expression (≥ 2-fold, p ≤0.05) of 4,204 genes in skin biopsies from 6 week-old WT (n = 5) and RIPK1^E-KO mice (n = 5). b, Functional annotation by gene ontology (GO) of the top n = 1,000 upregulated genes and the top n = 1,000 down regulated genes between the samples in a, performed with g:Profiler (https://biit.cs.ut.ee/gprofiler). P values were estimated by hypergeometric distribution tests and adjusted by multiple testing correction using the g:SCS (set counts and sizes) algorithm, integral to the g:Profiler server.