FIG 2.

Tree using established Children’s Oncology Group risk criteria plus individual histologic factors in lieu of International Neuroblastoma Pathology Classification in overall cohort 2 (ie, after combining the Test and Validation sets [n = 8,761]). Only the splits and terminal nodes that were identified in the Test set and subsequently confirmed in the Validation set, plus the clinical splits, have been presented. Colors are used for descriptive purposes only. (A) Top 2 splits by histology category and INSS stage. (B) Nodes within International Neuroblastoma Staging System (INSS) stages 1,2,3,4S. (C) Nodes within INSS stage 4. AMP, MYCN amplified; Diff, differentiating; diff-ing, differentiating; EFS, event-free survival; GNB, ganglioneuroblastoma; GNR, ganglioneuroma; HR, hazard ratio; int, intermediate; intmix/well diff, intermixed or well differentiated; matur, maturing; MKI, mitosis-karyorrhexis index; NB, neuroblastoma; nod, nodular; undiff-ed, undifferentiated.