FIG A3.

Tree using established Children’s Oncology Group risk criteria plus individual histologic factors in lieu of International Neuroblastoma Pathology Classification in cohort 2, Test set (n = 4,380). (A) Top 2 splits by histology category and INSS stage. (B) Nodes within INSS stages 1,2,3,4S. (C) Nodes within International Neuroblastoma Staging System (INSS) stage 4. Colors are used for descriptive purposes only. AMP, MYCN amplified; diff, differentiating; diff-ing, differentiating; EFS, event-free survival; GNB, ganglioneuroblastoma; GNR, ganglioneuroma; HR, hazard ratio; int, intermediate; intmix/well diff, intermixed or well differentiated; matur, maturing; MKI, mitosis-karyorrhexis index; NB, neuroblastoma; nod, nodular; undiff-ed, undifferentiated.