Table 1.
Patient Characteristics Between Groups of AZA Adherence and Nonadherence
| Features | Adherence (n=259) | Nonadherence (n=187) | P value |
|---|---|---|---|
| Male (n [%]) | 161(62.2) | 99(52.9) | 0.051 |
| Age (Mean ± SD) | 32.8±11.1 | 30.2±12.0 | 0.022 |
| Married (n [%]) | 137(52.9) | 81(43.3) | 0.046 |
| Offspring (n [%]) | 102(39.4) | 76(40.6) | 0.789 |
| Education (n [%]) | <0.001 | ||
| Primary school | 15(5.8) | 3(1.6) | |
| Secondary school | 36(13.9) | 13(7.0) | |
| High school | 95(36.7) | 41(21.9) | |
| College | 100(38.6) | 97(51.9) | |
| Postgraduate | 13(5.0) | 33(17.6) | |
| Family income per month (n [%]) | 0.986 | ||
| >10 thousand USD | 21(8.1) | 16(8.6) | |
| 5–10 thousand USD | 35(13.5) | 22(11.8) | |
| 2–5 thousand USD | 77(29.7) | 56(29.9) | |
| 1–2 thousand USD | 95(36.7) | 69(36.9) | |
| <1 thousand USD | 31(12.0) | 24(12.8) | |
| Cost of disease per year (n [%]) | 0.106 | ||
| >10 thousand USD | 67(25.9) | 40(21.4) | |
| 5–10 thousand USD | 100(38.6) | 91(48.7) | |
| <5 thousand USD | 92(35.5) | 56(29.9) | |
| Smoking (n [%]) | 9(3.5) | 11(5.9) | 0.225 |
| Alcoholism (n [%]) | 3(1.2) | 12(6.4) | 0.002 |
| Disease duration (yrs) (Mean ± SD) | 4.7±2.5 | 4.9±2.4 | 0.420 |
| Age of onset (n [%]) | 0.357 | ||
| <17 years old | 24(9.3) | 15(8.0) | |
| 17–40 years old | 217(83.8) | 152(81.3) | |
| >40 years old | 18(6.9) | 20(10.7) | |
| Location of lesions (n [%]) | 0.079 | ||
| Ileum | 113(43.6) | 91(48.7) | |
| Colon | 37(14.3) | 14(7.5) | |
| Ileocolon | 109(42.1) | 82(43.9) | |
| Behaviour (n [%]) | 0.382 | ||
| Non-stricture non-penetrating | 181(69.9) | 119(63.6) | |
| Stricture | 48(18.5) | 42(22.5) | |
| Penetrating | 30(11.6) | 26(13.9) | |
| Perianal disease (n [%]) | 83(32.0) | 59(31.6) | 0.912 |
| CD-related surgery (n [%]) | 44(17.0) | 40(21.4) | 0.241 |
| Anxiety (Mean ± SD) | 4.4±2.1 | 7.2±3.3 | <0.001 |
| Depression (Mean ± SD) | 5.9±2.9 | 7.3±3.1 | <0.001 |
| AZA usage (n [%]) | |||
| Dosage (mg/d) (Mean ± SD) | 67.3±24.8 | 66.5±22.4 | 0.719 |
| Duration (months) (Mean ± SD) | 34.8±16.2 | 33.5±17.8 | 0.429 |
| Necessity belief (Mean ± SD) | 18.0±1.2 | 15.8±2.6 | <0.001 |
| Concerns belief (Mean ± SD) | 14.8±2.0 | 17.0±1.8 | <0.001 |
| Knowledge (Mean ± SD) | 6.0±1.8 | 5.6±1.8 | 0.016 |
| Side effect (n [%]) | 28(10.8) | 18(9.6) | 0.685 |
Abbreviations: SD, standard deviation; CD, Crohn’s disease; AZA, azathioprine.