Table 3.
SI and RF values of target compounds 11–32.
| Compd. | SI (RF)a |
||||||
|---|---|---|---|---|---|---|---|
| L100I | K103N | Y181C | Y188L | E138K | F227L + V106A | RES056 | |
| 11 | 151 (5.0) | 651 (1.2) | 213 (3.6) | 253 (3.0) | 271 (2.8) | 158 (4.8) | 24 (31.9) |
| 12 | 70 (4.4) | 224 (1.4) | 57 (5.5) | 94 (3.3) | 101 (3.1) | 26 (11.9) | 10 (31.1) |
| 13 | 84 (2.9) | 249 (1.0) | 79 (3.1) | 117 (2.1) | 81 (3.0) | 44 (5.6) | 13 (18.8) |
| 14 | 60 (4.6) | 212 (1.3) | 88 (3.1) | 71 (3.9) | 89 (3.1) | 30 (9.1) | 19 (14.1) |
| 15 | 220 (2.0) | 932 (0.5) | 235 (1.9) | 203 (2.1) | 173 (2.5) | 380 (1.1) | 22 (20.2) |
| 16 | ≥28 (3.6) | ≥111 (0.9) | ≥28 (3.6) | ≥33 (3.0) | ≥31 (3.3) | ≥19 (5.4) | ≥2 (49.2) |
| 17 | 203 (2.4) | 865 (0.6) | 245 (2.0) | 249 (2.0) | 295 (1.7) | 272 (1.8) | 17 (29.5) |
| 18 | 18 (3.8) | 99 (0.7) | 23 (3.1) | 27 (2.6) | 23 (3.1) | 20 (3.6) | 4 (18.8) |
| 19 | 62 (7.9) | 356 (1.4) | 127 (3.8) | 176 (2.8) | 200 (2.4) | 106 (4.6) | 12 (39.1) |
| 20 | 42 (8.7) | 171 (2.1) | 89 (4.1) | 85 (4.3) | 120 (3.1) | 44 (8.3) | 10 (36.3) |
| 21 | 98 (2.8) | 289 (0.9) | 105 (2.6) | 114 (2.4) | 145 (1.9) | 136 (2.0) | 11 (25.6) |
| 22 | 50 (5.1) | 230 (1.1) | 85 (3.0) | 122 (2.1) | 90 (2.8) | 45 (5.7) | 12 (21.4) |
| 23 | 372 (4.0) | 1441 (1.0) | 377 (4.0) | 326 (4.6) | 547 (2.7) | 363 (4.1) | 43 (34.3) |
| 24 | 111 (4.8) | 578 (0.9) | 189 (2.8) | 132 (4.0) | 195 (2.7) | 120 (4.4) | 12 (44.9) |
| 25 | 194 (1.6) | 403 (0.8) | 173 (1.8) | 99 (3.2) | 120 (2.6) | 89 (3.5) | 51 (6.1) |
| 26 | 521 (1.1) | 910 (0.6) | 290 (1.9) | 229 (2.4) | 236 (2.3) | 56 (9.8) | 44 (12.6) |
| 27 | 569 (1.9) | 1639 (0.6) | 432 (2.4) | 256 (4.1) | 402 (2.6) | 285 (3.7) | 40 (26.1) |
| 28 | 83 (2.1) | 208 (0.9) | 81 (2.2) | 57 (3.1) | 99 (1.8) | 26 (6.7) | 10 (17.2) |
| 29 | 74 (3.1) | 189 (1.2) | 71 (3.3) | 68 (3.4) | 100 (2.3) | 131 (1.8) | 11 (21.2) |
| 30 | 21 (6.3) | 135 (1.0) | 40 (3.3) | 42 (3.2) | 96 (1.4) | 19 (7.1) | <1 (>133) |
| 31 | 46 (2.7) | 161 (0.8) | 48 (2.6) | 55 (2.3) | 112 (1.1) | 51 (2.4) | 4 (33.5) |
| 32 | 17 (6.9) | 93 (1.3) | 32 (3.8) | 36 (3.4) | 100 (1.2) | 25 (4.8) | 5 (26.2) |
| NVP | >7 (7.5) | >1 (42) | NA (>51.1) | NA (>51) | >82 (0.6) | NA (>51.1) | NA (>51.1) |
| EFV | >136 (8.8) | >57 (21) | >1000 (1.2) | >21 (58) | >1237 (1.0) | >24 (51.1) | >24 (51.0) |
| ETR | >723 (1.3) | >1463 (0.6) | >376 (2.4) | >264 (3.5) | >569 (1.6) | >322 (2.8) | >108 (8.4) |
a
RF is the ratio of EC50 (resistant viral strain)/EC50 (wild-type viral strain).