Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic profile of 26a.
| Subject | t1/2 | Tmax | Cmax | AUC0–last | AUC0–inf | CL | F |
|---|---|---|---|---|---|---|---|
| (h) | (h) | (ng/mL) | (h⋅ng/mL) | (h⋅ng/mL) | (mL/min/kg) | (%) | |
| 26 (i.v.)b | 1.71 ± 0.24 | – | 941 ± 181 | 1290 ± 62.7 | 1336 ± 53.9 | 25.0 ± 1.04 | – |
| 26 (p.o.)c | 2.68 ± 0.20 | 2.00 ± 0.32 | 762 ± 296 | 4359 ± 1570 | 4761 ± 1354 | – | 33.8 |
PK parameters (mean ± SD, n = 3).
Dosed i.v. at 2 mg/kg.
Dosed p.o. at 20 mg/kg –Not applicable.
