Table 3.
Cox regression analysis of association between clinical characteristics and disease progression in patients with COVID-19
| Variables | Univariable HR (95% CI) | Multivariable HR (95% CI) |
|---|---|---|
| Age, ≥65 years | 4.308 (3.364–5.516) | 2.563 (1.973–3.330) |
| Sex, male | 1.722 (1.359–2.182) | 1.793 (1.410–2.280) |
| Smoking history, versus no | 0.511 (0.317–0.823) | 0.559 (0.344–0.909) |
| Coexisting disorder, versus none | ||
| Hypertension | 2.540 (2.011–3.209) | 1.442 (1.109–1.876) |
| Diabetes | 2.920 (2.224–3.835) | 1.816 (1.351–2.442) |
| Chronic obstructive lung disease | 3.582 (2.478–5.178) | 2.010 (1.380–2.926) |
| Coronary artery disease | 2.459 (1.719–3.520) | 1.828 (1.256–2.660) |
| Chronic renal disease | 3.057 (1.513–6.174) | |
| Cerebrovascular disease | 2.410 (1.408–4.124) | |
| Hepatitis B infection | 0.333 (0.047–2.377) | |
| Anti-viral drug | 4.292 (2.695–6.837) | |
| Duration of anti-viral therapy | 4.689 (3.463–6.349) | 3.192 (2.329-4.375) |
Abbreviations: COVID-19, coronavirus disease 2019; HR, hazard ratio.