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Effect of rociletinib on the intracellular accumulation of DOX, Rho 123 in MDR cells and their parental cells. The accumulation of DOX (A), Rho 123 (B) in S1 and S1-MI-80 cells were measured by flow cytometric analysis as described in ‘‘Materials and methods’’ section. The results were presented as fold change in fluorescence intensity relative to control MDR cells. Data are expressed as mean ± SD from three independent experiments.
