Table 5.
IR Wavenumbers (cm−1) of AACONH2 and drug-loaded AACONH2.
| Formulation | Ester = C=O peak (cm−1) | Amide –NH2 peak 1 (cm−1) | Amide-NH2 peak 2 (cm−1) | Ester = C=O peak (cm−1) | Amide = C=O peak (cm−1) |
|---|---|---|---|---|---|
| 1-AACONH2 | 3453.0 | 3367.3 | 3182.8 | 1736.8 | 1692.5 |
| 1-ETO | 3451.2 | 3371.0a | 3196.2a | 1737.3 | None |
| 1-KET | 3451.9 | 3366.7 | 3192.3a | 1737.0 | None |
| 1-GEM | 3452.3 | 3366.1a | 3192.4a | 1737.2 | 1693.6 |
| 1-ZOL | 3452.6 | 3369.0 | 3190.7a | 1737.3 | 1692.0 |
| 1-PRO | 3453.4 | 3368.6 | 3190.0a | 1737.4 | 1692.1 |
| 1-LID | 3452.6 | 3366.8 | 3187.2a | 1737.3 | 1692.3 |
| 3-AACONH2 | 3452.2 | 3360.2 | 3194.7 | 1736.7 | 1689.4 |
| 3-ETO | 3450.7 | 3362.1 | 3120.0a | 1736.8 | 1690.3 |
| 3-KET | 3451.1 | 3360.0 | 3197.9a | 1736.8 | 1690.4 |
| 3-GEM | 3452.5 | 3359.7 | 3194.4 | 1737.1 | 1691.3 |
| 3-ZOL | 3449.8a | 3362.6a | 3197.6a | 1736.4 | 1689.0 |
| 3-PRO | 3452.9 | 3359.7 | 3193.1 | 1737.2 | 1690.2 |
| 3-LID | 3451.8 | 3359.7 | 3195.5 | 1736.8 | 1689.6 |
| 5-AACONH2 | 3450.2 | 3357.9 | 3198.6 | 1736.5 | 1688.1 |
| 5-ETO | 3450.8 | 3361.9a | 3200.5 | 1736.9 | 1690.3a |
| 5-KET | 3449.0 | 3358.2 | 3198.9 | 1736.5 | 1688.1 |
| 5-GEM | 3451.2 | 3357.7 | 3200.3 | 1737.0 | 1689.2 |
| 5-ZOL | 3446.8a | 3359.0 | 3199.8 | 1736.5 | 1687.3 |
| 5-PRO | 3450.7 | 3357.2 | 3200.3 | 1736.9 | 1688.3 |
| 5-LID | 3449.0 | 3358.4 | 3198.1 | 1736.8 | 1688.0 |
| 7-AACONH2 | 3444.4 | 3355.0 | 3200.2 | 1736.6 | 1687.1 |
| 7-ETO | 3444.7 | 3357.7a | 3201.0 | 1736.5 | 1687.2 |
| 7-KET | 3446.4a | 3356.3 | 3199.8 | 1736.5 | 1687.2 |
| 7-GEM | 3443.5 | 3354.2 | 3200.9 | 1736.8 | 1688.2 |
| 7-ZOL | 3442.5 | 3357.0a | 3200.4 | 1736.6 | 1686.0 |
| 7-PRO | 3446.1 | 3353.6 | 3201.0 | 1736.7 | 1687.6 |
| 7-LID | 3446.1 | 3356.4 | 3199.2 | 1736.7 | 1687.0 |
a
Wavenumber variation larger than 2.0 cm−1 was considered as significant.