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Pharmacokinetic parameters of transdermal and i.v. administrations (n = 6).
| Formulation | Tmax (h) | Cmax (ng/mL) | AUC (h·ng/mL) | MRT (h) |
|---|---|---|---|---|
| 1-AACONH2 | 3.30 ± 1.10 | 780.54 ± 126.94 | 10,180.83 ± 2619.01 | 9.99 ± 0.70 |
| 3-AACONH2 | 4.75 ± 2.22 | 682.69 ± 124.16 | 6942.08 ± 1113.59 | 10.13 ± 0.44 |
| 5-AACONH2 | 3.50 ± 0.58 | 522.61 ± 113.76 | 6528.83 ± 1681.43 | 9.96 ± 1.63 |
| 7-AACONH2 | 5.17 ± 2.23 | 217.74 ± 49.37 | 3379.14 ± 835.90 | 11.53 ± 1.07 |
| i.v. | – | – | 6893.56 ± 457.45 | 1.64 ± 0.12 |
–Not applicable.
