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IVIVC between in vitro percent of drug permeation (X) and in vivo percent of drug absorption (Y).
| ZOL Patch | IVIVC model | R |
|---|---|---|
| 1-AACONH2 | Y = 3.513 + 1.175X−0.012X2 | 0.9777 |
| 3-AACONH2 | Y = 0.938 + 1.182X−0.016X2 | 0.9934 |
| 5-AACONH2 | Y = 2.671 + 1.412X−0.026X2 | 0.9655 |
| 7-AACONH2 | Y = 0.530 + 0.891X−0.020X2 | 0.9953 |
