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. 2020 Feb 14;100(6):887–899. doi: 10.1038/s41374-020-0406-7

Fig. 7. Cardiac function and histopathology of cloned SGCD−/− pigs.

Fig. 7

Echocardiography was used to determine the dimensions and contractility of the LV of SGCD−/− pigs (M-38-3, 4, 5) at 5 weeks of age compared with those of age-matched normal animals (WT). Compared with the WT pigs (a), all three SGCD−/− animals showed dilated LV cavities during the systolic phase and thin LV walls, as shown in the M-mode echocardiographs (b–d). Masson’s trichrome staining of the cardiomyocytes suggested interstitial edema as indicated by the gaps between the cardiac muscle cells in the SGCD−/− pigs (f–h) compared with those of WT animals (e). Scale bars in (e–h), 100 µm. f SGCD−/− pig M38-3 at 7 weeks; g, h SGCD−/− pigs M38-4 and M38-5 at 8 weeks.