Table 2.
Cardiac performance of the progeny SGCD−/− pigs.
| Genotypes | Age (weeks) | LVDd (mm) | LV Ds (mm) | IVSth (mm) | PWth (mm) | LVEF (%)* |
|---|---|---|---|---|---|---|
| WT | 3 | 13.4 ± 0.6 | 7.0 ± 0.6 | 2.4 ± 0.0 | 2.4 ± 0.2 | 85.2 ± 2.7 |
| SGCD+/− | 3 | 15.7 ± 1.6 | 8.1 ± 1.2 | 2.5 ± 0.4 | 2.7 ± 0.1 | 85.7 ± 1.1 |
| SGCD−/− | 3 | 14.8 ± 1.0 | 8.0 ± 0.8 | 2.6 ± 0.1 | 2.6 ± 0.2 | 83.7 ± 1.9 |
| WT | 6 | 24.3 ± 3.6 | 13.6 ± 3.4 | 4.3 ± 0.3 | 4.7 ± 0.4 | 82.7 ± 5.2 |
| SGCD+/− | 6 | 29.5 ± 1.5 | 17.1 ± 1.7 | 4.9 ± 0.5 | 5.1 ± 0.3 | 80.4 ± 2.7 |
| SGCD−/− | 6 | 28.2 ± 5.2 | 18.8 ± 4.6 | 4.4 ± 0.3 | 4.5 ± 0.2 | 70.4 ± 6.3 |
| WT | 9 | 30.6 ± 3.1 | 18.4 ± 1.3 | 5.1 ± 0.3 | 5.2 ± 0.9 | 77.2 ± 2.9 |
| SGCD+/− | 9 | 31.4 ± 0.8 | 19.3 ± 1.1 | 5.9 ± 1.1 | 6.4 ± 0.7 | 76.3 ± 2.9 |
| SGCD−/− | 9 | 27.5 ± 3.4 | 21.1 ± 3.2 | 4.3 ± 0.6 | 4.6 ± 0.5 | 55.0 ± 3.8 |
Two to 5 animals were used in each group.
WT wild-type, SGCD+/− δ-SG gene heterozygous knockout pig, SGCD−/− δ-SG gene homozygous knockout pig, LVDd left ventricular diastolic dimension, LVDs left ventricular systolic dimension, IVSth interventricular septum thickness, PWth left ventricular posterior wall thickness, LVEF left ventricular ejection fraction.
*Values in the SGCD−/− group significantly differ from those in the WT and SGCD+/− groups at 9 weeks (LVEF: P < 0.001).