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. 2020 Jun 8;10:9251. doi: 10.1038/s41598-020-65849-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of dipentylammonium (DPA, 5 mg.kg⁻¹) and sigma-1 receptor antagonist BD1047 (4 mg.kg⁻¹) on despair behaviour in mice subjected to the forced-swim test. The control consisted of 10 ml.kg⁻¹ saline; fluoxetine (10 mg.kg⁻¹) was used as a positive control. Five mice were used for each data point. Error bars show SEM. ANOVA followed by Bonferroni post hoc multiple comparison gave: *control vs fluoxetine, P 0.0022; **control vs dipentylammonium, P < 0.0001; control vs BD1047, P = 0.13; ^##dipentylammonium vs BD1047 + dipentylammonium, P = 0.0001. This figure is reproduced from the PhD thesis by J.M. Brimson⁴⁴.