Fig. 2.
In vivo models commonly used in osteocyte mechanobiology. Examples of active loading models with the right ulna (a) and right tibia (b) in mice. Loading model mice were under avertin-induced anesthesia, and the right sides of the ulna and tibia were subjected to cyclic mechanical compression with a computationally controlled machine. The contralateral left limbs served as controls. Illustrations of ulna and tibia loading are highlighted in yellow and green boxes, respectively. c Illustration of the HLU model in mice.25 Experimental mice were outfitted with a tail harness, and their hindlimbs were suspended within customized cages. [panel c from Robling et al.25, reprinted with permission]