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. 2020 Jun 8;8:23. doi: 10.1038/s41413-020-0099-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Focal adhesions on the osteocyte cell body and dendrites. a Heterodimers of Integrin β3 with Integrins α1/2/3/4/5 are localized to the osteocyte cell body surface.²³ The heads of these heterodimers contact the pericellular matrix, and their tails are linked to the F-actin cytoskeleton. Moreover, the classical focal adhesion components Vinculin and Paxillin were reported to colocalize with Integrin β1-mediated focal adhesions.⁸³b Heterodimers of Integrin β3 with Integrin αv are localized to osteocyte dendritic surfaces.²³ The purinergic channel pannexin 1, the ATP-gated purinergic receptor P2X7R and the low-voltage transiently opened T-type calcium channel CaV3.2-1 reside in close proximity to Integrin β3 attachment foci.⁸³c Illustration of major focal adhesion components at cell-ECM interphases.^165,166