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. 2020 Jun 8;11(6):440. doi: 10.1038/s41419-020-2644-4

Fig. 4. IFN-γ administration promotes microglial clearance of Aβ.

Fig. 4

a Representative image of staining with anti-Aβ (purple) and Hoechst (blue) in the cortical and hippocampal areas of APP/PS1 mice treated with IFN-γ or not. Scale bar = 50 μm. b Quantification of the Aβ burden in the cortex and hippocampus in APP/PS1 mice. *P < 0.05, **P < 0.01, ***P < 0.001. Data were analyzed by Student’s t-test and are presented as the mean ± SEM. (n = 6/group) c Representative images of staining with anti-Aβ (purple), TMEM119 (red), Iba-1 (green) and Hoechst (blue) in APP/PS1 mice treated with IFN-γ or not. Scale bar = 10 μm. d, e IFN-γ enhances the phagocytic activity of microglia. Representative density plots and quantification show the percentages of microglia (TMEM119) containing Aβ (Methoxy-X04) in APP/PS1 mouse brains after IFN-γ treatment. APP/PS1: n = 5 mice; APP/PS1 + IFN-γ: n = 4 mice. *P < 0.05. Data were analyzed by Student’s t-test and are presented as the mean ± SEM.