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. 2020 Jun 8;11(6):437. doi: 10.1038/s41419-020-2635-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The expression of circSLC25A16 was detected using RT-PCR in NSCLC cells (H460, H1299, A549) and normal cells (NHBE). b In A549 cells, shRNAs specifically targeting circSLC25A16 were transfected to knock down its expression, and overexpression plasmids (OE) was transfected to enhance circSLC25A16 expression. c Glucose uptake analysis, d lactate production analysis and e ATP analysis demonstrated the glucose utilization in A549 cells transfected with circSLC25A16 shRNA (sh-circSLC25A16) and circSLC25A16 overexpression (OE), as well as controls. f ECAR analysis (extracellular acidification rate) showed the glycolytic capacity of A549 cells transfected with circSLC25A16 shRNA (sh-circSLC25A16) and circSLC25A16 overexpression (OE). *p < 0.05. **p < 0.01.